ProSci

DRAM Antibody

Product Code:
 
PSI-33-062
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
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Western blot testing of human samples using DRAM antibody at 4ug/ml.
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Western blot testing of human samples using DRAM antibody at 4ug/ml.

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PSI-33-062-100ug100ug£662.00
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Further Information

Additional Names:
DRAM Antibody: DRAM, DRAM, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator
Application Note:
Western blot: 4-8 ug/ml

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Background:
Autophagy is the mechanism by which lysosomes degrade unneeded or dysfunctional cellular components. p53 is a tumor suppressor protein that modulates autophagy and apoptosis. DRAM, or damage regulated autophagy modulator, is a lysosomal protein and effector of p53-mediated cell death. Many tumors show decreased DRAM expression and siRNA knockdown resulted in reduced cell death (Crighton et al, 2006).
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the N-terminal region of human DRAM was used as the immunogen for this antibody.
NCBI Gene ID #:
55332
NCBI Official Name:
damage-regulated autophagy modulator
NCBI Official Symbol:
DRAM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A affinity chromatography
Research Area:
Apoptosis,Autophagy,Cancer
Swissprot #:
Q8N682
User NOte:
Optimal dilutions for each application to be determined by the researcher