ProSci

CD28 Antibody [AV7] (Biotin)

Product Code:
 
PSI-99-238
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[AV7]
Regulatory Status:
 
RUO
Target Species:
  • Chicken (Gallus)
  • Turkey
Applications:
  • Blocking
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
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PSI-99-238-0.5mg0.5mg£686.00
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Further Information

Application Note:
CD28 Antibody [AV7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and immunoprecipitation assays.
Background:
Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on antigen presenting cells. Peripheral gammadelta+ T cells are CD28 negative. Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A, or monoclonal antibodies against the avian T cell receptor (TCR). Both Vbeta1- and Vbeta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A but inhibited by herbimycin A suggesting that CD28 employs a signaling pathway at least partly distinct from that triggered by TCR/CD3. The monoclonal antibody AV7 also reacts with turkey CD28 as demonstrated by flow cytometry.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Chicken peripheral blood lymphocytes
NCBI Gene ID #:
396249
NCBI Official Name:
CD28 molecule
NCBI Official Symbol:
CD28
NCBI Organism:
Gallus gallus
Physical State:
Liquid
Protein Accession #:
P31043
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD28
Swissprot #:
P31043
User NOte:
Optimal dilutions for each application to be determined by the researcher.