ProSci

SIN1 Antibody

Product Code:
 
PSI-33-014
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
1 / 1
Western blot testing of human samples with SIN1 antibody at 1ug/ml.
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Western blot testing of human samples with SIN1 antibody at 1ug/ml.

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CodeSizePrice
PSI-33-014-100ug100ug£662.00
Quantity:
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This product comes from: United States.
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Further Information

Additional Names:
MAPKAP1 Antibody: MIP1, SIN1, JC310, SIN1b, SIN1g, MIP1, Target of rapamycin complex 2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, TORC2 subunit MAPKAP1
Application Note:
Western blot: 1-3 ug/ml

Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.
Background:
mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.
NCBI Gene ID #:
79109
NCBI Official Name:
mitogen-activated protein kinase associated protein 1
NCBI Official Symbol:
MAPKAP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Signal Transduction
Swissprot #:
Q9BPZ7
User NOte:
Optimal dilutions for each application to be determined by the researcher