Rabbit anti Human Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)
Antibody Clonality:
Polyclonal
Shipping:
Ship at ambient temperature freeze upon arrival
Storage:
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
No additional charges, what you see is what you pay! *
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available!
Contact us to find what you can save.
This product comes from:
Netherlands.
Typical lead time:
7-10 working days.
Contact us for more accurate information.
- Further Information
- References
- Show All
Further Information
Applications Description:
Detects EDG6 receptors at concentration of 5-10 ?g/ml by Western blot using a human EDG6 receptor transfected cell line. Detects an approximately 45 kDa band in Cos cells transfected with full length human EDG6. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. Optimal concentration should be evaluated by serial dilutions.
EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
See vial for concentration
Signal Transduction
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Western Blotting
Synthetic peptide derived from the C-terminal of the EDG-6 receptor
RH7777 cells transfected with EDG6 protein (Cat. No. X1311C)
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Unconjugated
Products are stable for one year from purchase when stored properly
Ammonium Sulfate Precipitation
Rabbits were immunized with a synthetic peptide derived from the C-terminal of the EDG-6 receptor
Endothelial cell differentiation gene 6 C-terminal; Sphingosine-1-Phosphate Receptor-4 (S1P-4)
O95977