GTF2H2 Antibody

GTF2H2, BTF2, BTF2P44, MGC102806, T-BTF2P44, TFIIH, p44

WB: 1:500 - 1:2000

IHC: 1:50 - 1:200

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GTF2H2 (NP_001506.1).

2966

general transcription factor IIH, polypeptide 2, 44kDa

GTF2H2

Homo sapiens

Liquid

Observed: 44kDa

Affinity purification

Transcription

Q13888

Optimal dilutions for each application to be determined by the researcher.