AdipoGen Life Sciences

FGF-21 (human) (rec.)

Product Code:
 
AG-40A-0091Y
Product Group:
 
Recombinant Proteins
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Blue Ice
Storage:
 
-20°C
 

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CodeSizePrice
AG-40A-0091Y-C01010 ug£120.00
Quantity:
AG-40A-0091Y-C05050 ug£320.00
Quantity:
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Further Information

Alternate Names/Synonyms:
Fibroblast Growth Factor 21
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Protein. Human FGF-21 (aa 29-209) is fused at the C-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Liquid. Contains PBS. Purity: >90% (SDS-PAGE). FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
Molecular Weight:
~22kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9NSA1
Package Type:
Plastic Vial
Product Description:
The fibroblast growth factor (FGF) family is a group of multifunctional signaling molecules that have a wide variety of functions. The family comprises of 22 related proteins, each grouped into subfamilies which are based on genetic and functional similarity. FGF21 is expressed in several tissues such as liver (main site), muscles, adipocytes, pancreas, and brain where it passes the blood-brain barrier. FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. Its activity requires the presence of the FGFR1 and beta-klotho. FGF21 mediates the adaptive starvation response to induce ketogenesis, gluconeogenesis, lipolysis, and lipid beta-oxidation. FGF21 plays also a key role in cardiac remodeling with the heart expressing fibroblast growth factor receptor 1 (FGFR1), beta-klotho, as well as FGF21. In muscle, FGF21 expression in skeletal muscles is due to mitochondrial dysfunction and ER stress.
Purity:
>90% (SDS-PAGE)
Sequence:
Human FGF-21 (aa 29-209) is fused at the C-terminus to a FLAG®-tag.
Source / Host:
HEK 293 cells
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.