ProSci

Famotidine

Product Code:
 
PSI-10-026
Product Group:
 
Inhibitors and Activators
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
blue ice
Storage:
 
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
 

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PSI-10-026-5g5g£336.00
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Further Information

Additional Names:
MK-208; YM-11170; Pepcid; N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
Background:
Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex). Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively). Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs). Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.
CAS:
76824-35-6
Formula:
C8H15N7O2S3
Identity:
Determined by 1H-NMR.
InChi Key:
XUFQPHANEAPEMJ-UHFFFAOYSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
337.5
Purity:
greater than or equal to 98% (HPLC)
Smiles:
N/C(N)=N/C1=NC(CSCC/C(N)=N/S(=O)(N)=O)=CS1
Solubility:
Soluble in DMSO (30mg/ml) or DMF (25mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (30mg/ml) or DMF (25mg/ml).

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