ProSci

Oseltamivir . phosphate

Product Code:
 
PSI-10-036
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
blue ice
Storage:
 
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
 

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PSI-10-036-250mg250mg£336.00
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Further Information

Additional Names:
GS-4104; Ro 64-0796/002; Tamiflu
Background:
Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. It is an antiviral prodrug targeted against the influenza viruses. Once hydrolyzed in the liver to its active metabolite, oseltamivir carboxylate, it can competitively inhibit viral neuraminidase (IC50s=0.1-4.9nM for influenza neuraminidases A and B). The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir is blocking the release of new viral particles from a host cell. Oseltamivir phosphate is used clinically to treat influenza A and influenza B and to prevent flu after exposure. It potentially could be used to reduce the spread of the SARS-CoV-2 and counteract against the transmission of COVID-19
CAS:
204255-11-8
Formula:
C16H28N2O4 . H3PO4
Identity:
Determined by 1H-NMR.
InChi Key:
POPJIXMLXGJJOV-ZFSDTUNKSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
312.4 . 98.0
Purity:
greater than or equal to 98% (HPLC)
Smiles:
O=P(OO)=O.N[C@@H]1[C@@H](NC(C)=O)[C@H](OC(CC)CC)C=C(C(OCC)=O)C1.[HH]
Solubility:
Soluble in DMSO (50mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (50mg/ml).

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