ProSci

ApolipoRecombinant Protein E / APOE Recombinant Protein

Product Code:
 
PSI-11-256
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-11-256-0.1mg0.1mg£657.00
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This product comes from: United States.
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Further Information

Additional Names:
Apolipoprotein E,APOE,Apo-E
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 36.1 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.
Background References:
  • Arnon R, et al. 1991. Biochim Biophys Acta. 1085(3):336-42.
  • Ji ZS, et al. 1997. J Biol Chem. 272(50):31285-92.
  • Marcel YL, et al. 1983. Biochim Biophys Acta. 750(2):411-7.
Buffer:
PBS, 5 mM CHAPS, 2 mM DTT, pH 7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
36.1 kDa
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells

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