ProSci

Mucin-1 / MUC-1 (1036-1155) Recombinant Protein

Product Code:
 
PSI-11-281
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-11-281-0.1mg0.1mg£729.00
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Further Information

Additional Names:
Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 7.2 kD
Background:
Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
Background References:
  • Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
  • Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
  • Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
  • Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
7.2 kDa (partial α chain) & 8.2 kDa (partial β chain)
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells

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