ProSci

CD34 Recombinant Protein

Product Code:
 
PSI-11-132
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-132-0.1mg0.1mg£838.00
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Further Information

Additional Names:
CD34,RP11-328D5.2
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.4 kDa. The protein migrates as 67-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.
Background References:
  • Simmons DL, et al., 1992, J. Immunol. 148 : 267?71.
  • Satterthwaite AB, et al., 1992, Genomics 12 (4): 788?94.
  • Nielsen JS, McNagny KM., 2008, J of Cell Science 121 (Pt 22): 3682?3692.
  • Berg EL, et al., 1998, Am. J. Pathol. 152 (2): 469?77.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
947
NCBI Official Name:
CD34molecule
NCBI Official Symbol:
CD34
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
29.4 kDa
Protein Accession #:
NP_001020280.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P28906

Documents