ProSci

Frizzled-10 / FZD10 Recombinant Protein

Product Code:
 
PSI-11-179
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-179-0.1mg0.1mg£729.00
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Further Information

Additional Names:
Fz-10,FZD10,hFz10,FzE7,CD350
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD10 contains one FZ (frizzled) domain. FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function. FZD10 interacts with WNT7B and MYOC.
Background References:
  • Dorsam RT, Gutkind JS, Nat Rev Cancer. 2007 Feb; 7(2):79-94.
  • Wang, Z. et al. (2005) Mol. Cell. Biol. 25:5022.
  • Kwon HS, et al. Mol Cell Biol. 2009.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
11211
NCBI Official Name:
frizzledclassreceptor10
NCBI Official Symbol:
FZD10
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
18.0 kDa
Protein Accession #:
NP_009128.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9ULW2

Documents