ProSci

B7-H4 Recombinant Protein

Product Code:
 
PSI-11-436
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-436-0.1mg0.1mg£867.00
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This product comes from: United States.
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Further Information

Additional Names:
B7-H4,VTCN1,B7S1,B7h.5
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Background References:
  • Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
  • Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
  • Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
NCBI Gene ID #:
79679
NCBI Official Name:
V-set domain containing T cell activation inhibitor 1
NCBI Official Symbol:
VTCN1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
51.8 kDa
Protein Accession #:
NP_078902.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q7Z7D3

Documents