ProSci

NRG1 Beta 1 Recombinant Protein

Product Code:
 
PSI-11-224
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-224-0.1mg0.1mg£657.00
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Further Information

Additional Names:
NRG1 Beta 1,HRG1 beta 1,Neuregulin-1 beta 1,Neuregulin1 beta 1,NRG1,ARIA,GGF,HGL,HRGA,NDF,SMDF
Application Note:
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-80 kDa and 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Background References:
  • Britsch S. Adv Anat Embryol Cell Biol. 2007. 190:1-65.
  • Talmage DA. Novartis Found Symp. 2008. 289:74-84.
  • Orr-Urtreger A, et al. Proc Natl Acad Sci U S A. 1993. 90(5):1867-71.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
NCBI Gene ID #:
3084
NCBI Official Name:
neuregulin1
NCBI Official Symbol:
NRG1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
53.2 kDa
Protein Accession #:
NP_039250.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q02297

Documents