ProSci

NOTCH1 Recombinant Protein

Product Code:
 
PSI-11-200
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-200-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
NOTCH1,Notch 1,hN1,TAN1
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.4 kDa. The protein migrates as 58-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Background References:
  • Wu L, et.al. Nat Genet. 2000. 26(4):484-9.
  • Wu L, et.al. Mol Cell Biol. 2002. 22(21):7688-700.
  • Zhou S, et al. Mol Cell Biol. 2000. 20(7):2400-10.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
18128
NCBI Official Name:
notch1
NCBI Official Symbol:
Notch1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
55.4 kDa
Protein Accession #:
NP_032740.3
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q01705

Documents