Chemodex

7-Hydroxycoumarin-3-carboxylic acid

Product Code:
 
CDX-H0015
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
AMBIENT
Storage:
 
Short Term: +4°C, Long Term: -20°C
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Chemical Structure
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Chemical Structure

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CDX-H0015-M100100 mg£181.00
Quantity:
CDX-H0015-G0011 g£926.00
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Further Information

Alternate Names/Synonyms:
Umbelliferone-3-carboxylic acid; HCC; NSC 115545; 7-OHCCA
Appearance:
Beige crystalline powder.
CAS:
779-27-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C10H6O5/c11-6-2-1-5-3-7(9(12)13)10(14)15-8(5)4-6/h1-4,11H,(H,12,13)
InChiKey:
LKLWLDOUZJEHDY-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 779-27-1. Formula: C10H6O5. MW: 206.15. Synthetic. 7-Hydroxycoumarin-3-carboxylic acid is one of the most popular blue fluorophores for labeling proteins and nucleic acids mostly through the in situ formation of its succinimidyl ester. It is also used to label peptides, nucleotides and carbohydrates. This coumarin is used as a fluorogenic substrate for glycosyltransferase assays and as a pH-indicator. Spectral data: Ex/Em = 386/448 nm (TRIS, pH9). Shown to have cytotoxic activity in some cancer cells.
MDL:
MFCD00017491
Molecular Formula:
C10H6O5
Molecular Weight:
206.15
Package Type:
Vial
Precautions:
P261-P305 + P351 + P338
Product Description:
7-Hydroxycoumarin-3-carboxylic acid is one of the most popular blue fluorophores for labeling proteins and nucleic acids mostly through the in situ formation of its succinimidyl ester. It is also used to label peptides, nucleotides and carbohydrates. This coumarin is used as a fluorogenic substrate for glycosyltransferase assays and as a pH-indicator. Spectral data: Ex/Em = 386/448 nm (TRIS, pH9). Shown to have cytotoxic activity in some cancer cells.
Purity:
>98% (TLC)
Signal word:
Warning
SMILES:
OC1=CC=C2C(OC(C(C(O)=O)=C2)=O)=C1
Solubility Chemicals:
Soluble in DMF, DMSO or methanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) H. Offenbacher, et al.; Sens. Actuators 9, 73 (1986) | (2) H. Li, et al.; J. Cell Biol. 134, 1019 (1996) | (3) K. Higai, et al.; Biol. Pharm. Bull. 22, 333 (1999) | (4) B. Thati, et al.; Cancer Lett. 248, 321 (2007) | (5) R.W. Sabnis; Handbook of Fluorescent Dyes and Probes p246 (2015)