Further Information
Alternate Names/Synonyms:
LY2835219 methanesulfonate; Abemaciclib methanesulfonate; Abemaciclib mesylate; Bemaciclib
Off-white powder.
1231930-82-7
32160000
liquid
GHS07
Protect from light and moisture.
InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
NCJPFQPEVDHJAZ-UHFFFAOYSA-N
Chemical. CAS: 1231930-82-7. Formula: C27H32F2N8 . CH4O3S. MW: 602.7. LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
MFCD25562906
C27H32F2N8 . CH4O3S
602.7
Vial
P261, P305+351+338, P302+352
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
>99%
Warning
CCN(CC1)CCN1CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2.CS(=O)(O)=O
Soluble in DMSO (20mg/ml) or water (30mg/ml).
Non-hazardous
Biochemical Reagents
12352200
Stable for at least 2 years after receipt when stored at RT.