NSJ Bioreagents

Myofibroblast Antibody

Product Code:
 
NSJ-V8295
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
PR 2D3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store the Myofibroblast antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
1 / 2
Western blot testing of human samples with Myofibroblast antibody (clone PR 2D3). ~
2 / 2
SDS-PAGE analysis of purified, BSA-free Myofibroblast antibody (clone PR 2D3) as confirmation of integrity and purity.

Western blot testing of human samples with Myofibroblast antibody (clone PR 2D3). ~
SDS-PAGE analysis of purified, BSA-free Myofibroblast antibody (clone PR 2D3) as confirmation of integrity and purity.

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CodeSizePrice
NSJ-V8295-20UG20 ug£264.00
Quantity:
NSJ-V8295-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details :
Western blot: 1-2ug/ml
Application Note:
Optimal dilution of the antibody should be determined by the researcher.
Description:
Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis, inflammation, repair, wound contraction and fibrosis. Like smooth muscle (SM) cells, myofibroblasts contain microfilament bundles and express -SM Actin, the Actin isoform that is present in myoepithelial cells and SM cells and especially abundant in vascular SM cells. Myofibroblasts secrete inflammatory and anti-inflammatory cytokines, chemokines, growth factors and lipid and gaseous inflammatory mediators, as well as extracellular matrix proteins and proteases in most organs and tissues. Besides being temporarily present following tissue injuries and fibrocontractive diseases, myofibroblasts are also present under normal conditions in regions such as the skin, pulmonary septa and periodontal ligaments. Stem cell factor and platelet-derived growth factor (PDGF) are two secreted proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
Format :
Purified
Formulation :
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
Crude homogenate of normal human colorectal mucosa was used as the immunogen for this Myofibroblast antibody.
Limitation:
This Myofibroblast antibody is available for research use only.
Purity:
Protein G affinity chromatography
Species Reactivity :
Human