SUMO-2 Antibody

Western blot: 1:1000

Titration of the SUMO-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

This SUMO-2 antibody was produced from rabbits immunized with a KLH conjugated synthetic peptide from the human protein.

This SUMO-2 antibody is available for research use only.

Purified

Human

P61956