NSJ Bioreagents

Dnmt1 Antibody

Product Code:
 
NSJ-F53105
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the Dnmt1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot analysis of lysate from human K562 and mouse F9 cell line using Dnmt1 antibody at 1:1000. Predicted molecular weight: 180-200 kDa
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Western blot analysis of lysate from human K562 and mouse F9 cell line using Dnmt1 antibody at 1:1000. Predicted molecular weight: 180-200 kDa

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CodeSizePrice
NSJ-F53105-0.08ML0.08 ml£260.00
Quantity:
NSJ-F53105-0.4ML0.4 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western blot: 1:500-1000
Application Note:
Titration of the Dnmt1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. Three families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 881-914 from the mouse protein was used as the immungen for the Dnmt1 antibody.
Limitation:
This Dnmt1 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse
Uniprot #:
P13864