NSJ Bioreagents

EED Antibody

Product Code:
 
NSJ-F53203
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the EED antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
1 / 1
Western blot testing of EED antibody at 1:1000 dilution. Lane 1: A431 lysate; 2: NIH3T3 lysate; Predicted molecular weight: 50 kDa (isoform 1), 53 kDa (isoform 2), 46 kDa (isoform 3).
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Western blot testing of EED antibody at 1:1000 dilution. Lane 1: A431 lysate; 2: NIH3T3 lysate; Predicted molecular weight: 50 kDa (isoform 1), 53 kDa (isoform 2), 46 kDa (isoform 3).

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CodeSizePrice
NSJ-F53203-0.08ML0.08 ml£260.00
Quantity:
NSJ-F53203-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:1000
Application Note:
Titration of the EED antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
This EED antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 269-303 amino acids from the central region of mouse Eed.
Limitation:
This EED antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse
Uniprot #:
Q921E6