IL-38 (aa 3-152) (mouse) (rec.) (FLAG)
Product Code:
AG-40B-0101
AG-40B-0101
Host Type:
E.coli
E.coli
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Shipping:
BLUE ICE
BLUE ICE
Storage:
Short Term Storage: +4?C. Long Term Storage: -20?C
Short Term Storage: +4?C. Long Term Storage: -20?C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-40B-0101-C010 | 10 ug | £290.00 |
Quantity:
| AG-40B-0101-3010 | 3 x 10 ug | £570.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
Concentration:
0.1mg/ml after reconstitution
EClass:
32160000
Endotoxin:
<0.01EU/?g purified protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized. Contains PBS + 0.5% Trehalose + 0.02% CHAPS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20?C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG?-tag. Source: E. coli. Endotoxin content: <0.01EU/?g purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.5% Trehalose. Purity: >95% (SDS-PAGE). IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
Molecular Weight:
~20kDa
NCBI, Uniprot Number:
Q8R459
Package Type:
Plastic Vial
Product Description:
IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
Purity:
>95% (SDS-PAGE)
Sequence:
Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG?-tag.
Source / Host:
E. coli
TAGs:
FLAG
Transportation:
Non-hazardous
UNSPSC Category:
Interleukins
UNSPSC Number:
41116127
Use & Stability:
Stable for at least 6 months after receipt when stored at -20?C. Working aliquots are stable for up to 3 months when stored at -20?C.
Documents
References
In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice: M. Chu, et al.; Immunobiology 222, 483 (2017) | The effect of interleukin 38 on angiogenesis in a model of oxygen-induced retinopathy: J. Zhang, et al.; Sci. Rep. 7, 2756 (2017) | The enigmatic role of IL-38 in inflammatory diseases: T. Garraud, et al.; Cytokine Growth Factor Rev. 39, 26 (2018) | Interleukin 38 protects against lethal sepsis: F. Xu, et al.; J. Infect. Dis. 218, 1175 (2018) | Interleukin?38 alleviates cardiac remodelling after myocardial infarction: Y. Wei, et al.; J. Cell. Mol. Med. 24, 371 (2020) | IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis: W.D. Xu, et al.; J. Cell Mol. Med. 24,12379 (2020)