ProSci

BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018 Antibody, Monoclonal

Product Code:
 
PSI-21-852
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Recombinant Antibody
Regulatory Status:
 
RUO
Storage:
 
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4?C short term (1-2 weeks). Store at -20 ?C 12 months. Store at -80?C long term.
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PSI-21-852-0.1mg0.1mg£657.00
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Further Information

Additional Names:
BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018, IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8
Background:
HuMax-IL8(BMS-986253) is a novel fully human monoclonal antibody that binds to and inhibits IL-8, a chemokine that promotes immune escape and tumor progression. Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Buffer:
PBS buffer pH 7.5
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Humanized / IL-8 (Granulocyte chemotactic protein 1, Monocyte-derived neutrophil-activating peptide, IL-8 (1-77), IL-8 (9-77), Monocyte-derived neutrophil chemotactic factor, IL-8 (7-77), (Ser-IL-8)72, GCP/IL-8 protein V, MONAP, C-X-C motif chemokine 8, GCP/IL-8 protein I, Neutrophil-ac ) [Homo sapiens]
NCBI Gene ID #:
3576
NCBI Official Name:
C-X-C motif chemokine ligand 8
NCBI Official Symbol:
CXCL8
NCBI Organism:
Homo sapiens
Protein Accession #:
P10145
Purification:
>95%
Purity:
>95%
Research Area:
Drug Analogues
Source:
CHO cells
Swissprot #:
P10145
User NOte:
For research use only .