TargetMol

GNF-PF-3777

Product Code:
 
TAR-T10199
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10199-1mg1mg£132.00
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Quantity:
TAR-T10199-1mL1 mL * 10 mM (in DMSO)£221.00
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TAR-T10199-5mg5mg£237.00
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TAR-T10199-10mg10mg£321.00
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TAR-T10199-25mg25mg£493.00
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TAR-T10199-50mg50mg£680.00
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TAR-T10199-100mg100mg£930.00
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Quantity:
TAR-T10199-500mg500mg£1,781.00
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Further Information

Bioactivity:
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
CAS:
77603-42-0
Formula:
C15H7N3O4
Molecular Weight:
293.238
Pathway:
Metabolism
Purity:
0.9947
SMILES:
[O-][N+](=O)c1ccc-2c(c1)C(=O)c1nc3ccccc3c(=O)n-21
Target:
IDO; Indoleamine 2,3-Dioxygenase (IDO)

References

1. Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. 2. Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. 3. Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67.