TargetMol

A-395

Product Code:
 
TAR-T10205
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10205-1mg1mg£103.00
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TAR-T10205-2mg2mg£116.00
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TAR-T10205-5mg5mg£142.00
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TAR-T10205-1mL1 mL * 10 mM (in DMSO)£147.00
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TAR-T10205-10mg10mg£195.00
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TAR-T10205-25mg25mg£369.00
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TAR-T10205-50mg50mg£550.00
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TAR-T10205-100mg100mg£755.00
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Further Information

Bioactivity:
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC50: 18 nM).
CAS:
2089148-72-9
Formula:
C26H35FN4O2S
Molecular Weight:
486.65
Pathway:
Chromatin/Epigenetic
Purity:
0.9782
SMILES:
CN(C)[C@H]1CN(C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(C)(=O)=O)C1CCc2cccc(F)c12
Target:
Histone Methyltransferase

References

1. He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13(4):389-395.