TargetMol

ACT-389949

Product Code:
 
TAR-T10242
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10242-1mg1mg£201.00
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Quantity:
TAR-T10242-5mg5mg£348.00
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TAR-T10242-10mg10mg£464.00
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TAR-T10242-25mg25mg£702.00
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TAR-T10242-50mg50mg£946.00
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Quantity:
TAR-T10242-100mg100mg£1,259.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.
CAS:
1258417-54-7
Formula:
C20H18F2N6O3
Molecular Weight:
428.4
Purity:
0.9719
SMILES:
Cc1nc(C(=O)Nc2cnn(Cc3nc(co3)C(C)(F)F)n2)c(o1)-c1cccc(C)c1

References

1. Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486. 2. Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.