TargetMol

AM103

Product Code:
 
TAR-T10314
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10314-1mg1mg£217.00
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TAR-T10314-2mg2mg£290.00
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TAR-T10314-5mg5mg£442.00
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TAR-T10314-10mg10mg£619.00
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TAR-T10314-25mg25mg£930.00
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TAR-T10314-50mg50mg£1,235.00
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Quantity:
TAR-T10314-100mg100mg£1,637.00
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Further Information

Bioactivity:
AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).
CAS:
1147872-22-7
Formula:
C36H38N3NaO4S
Molecular Weight:
631.76
Pathway:
Immunology/Inflammation
Purity:
0.9921
SMILES:
[Na+].COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C([O-])=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)cc1
Target:
FLAP

References

1. Hutchinson JH, et al. 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). J Med Chem. 2009 Oct 8;52(19):5803-15. 2. Lorrain DS, et al. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. J Pharmacol Exp Ther. 2009 Dec;331(3):1042-50.