TargetMol

AR antagonist 1

Product Code:
 
TAR-T10359
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10359-1mg1mg£177.00
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Quantity:
TAR-T10359-1mL1 mL * 10 mM (in DMSO)£303.00
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Quantity:
TAR-T10359-5mg5mg£313.00
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TAR-T10359-10mg10mg£430.00
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Quantity:
TAR-T10359-25mg25mg£663.00
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Quantity:
TAR-T10359-50mg50mg£863.00
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Quantity:
TAR-T10359-100mg100mg£1,179.00
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Quantity:
TAR-T10359-500mg500mg£2,311.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
CAS:
1818885-54-9
Formula:
C15H19ClN2O
Molecular Weight:
278.78
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](N)C2(C)C)C=C1Cl
Target:
Androgen Receptor

References

1. Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.