TargetMol

ARS-1323-alkyne

Product Code:
 
TAR-T10374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10374-100mg100mgEnquire
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TAR-T10374-500mg500mgEnquire
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TAR-T10374-5mg5mg£457.00
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TAR-T10374-10mg10mg£724.00
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TAR-T10374-1mL1 mL * 10 mM (in DMSO)£812.00
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TAR-T10374-25mg25mg£1,332.00
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Further Information

Bioactivity:
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
CAS:
2436544-27-1
Formula:
C28H27ClF2N6O3
Molecular Weight:
569
Pathway:
MAPK; GPCR/G Protein
Purity:
0.98
SMILES:
O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
Target:
Ras

References

1. Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.