TargetMol

BOC-D-FMK

Product Code:
 
TAR-T10580
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10580-1mg1mg£108.00
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TAR-T10580-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T10580-5mg5mg£189.00
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TAR-T10580-10mg10mg£249.00
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TAR-T10580-25mg25mg£409.00
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TAR-T10580-50mg50mg£581.00
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Quantity:
TAR-T10580-100mg100mg£781.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).
CAS:
634911-80-1
Formula:
C11H18FNO5
Molecular Weight:
263.26
Pathway:
Apoptosis; Proteases/Proteasome
Purity:
0.98
SMILES:
COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF
Target:
Apoptosis; Caspase

References

1. Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. 2. Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42. 3. Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9. 4. Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181(2):190-203.