TargetMol

BRD0705

Product Code:
 
TAR-T10606
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10606-1mg1mg£274.00
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TAR-T10606-2mg2mg£362.00
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TAR-T10606-5mg5mg£503.00
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TAR-T10606-1mL1 mL * 10 mM (in DMSO)£540.00
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TAR-T10606-10mg10mg£695.00
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TAR-T10606-25mg25mg£1,018.00
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TAR-T10606-50mg50mg£1,372.00
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TAR-T10606-100mg100mg£1,821.00
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This product comes from: United States.
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Further Information

Bioactivity:
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).
CAS:
2056261-41-5
Formula:
C20H23N3O
Molecular Weight:
321.424
Pathway:
PI3K/Akt/mTOR signaling; Stem Cells
Purity:
0.9959
SMILES:
CC[C@@]1(C2=CNNC2=NC2=C1C(=O)CC(C)(C)C2)c1ccccc1
Target:
GSK-3

References

1. Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.