TargetMol

C-021 dihydrochloride

Product Code:
 
TAR-T10639
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10639-1mg1mg£125.00
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TAR-T10639-5mg5mg£240.00
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TAR-T10639-1mL1 mL * 10 mM (in DMSO)£288.00
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TAR-T10639-10mg10mg£325.00
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TAR-T10639-25mg25mg£528.00
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TAR-T10639-50mg50mg£726.00
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TAR-T10639-100mg100mg£978.00
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Further Information

Bioactivity:
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.
CAS:
1784252-84-1
Formula:
C27H43Cl2N5O2
Molecular Weight:
540.57
Pathway:
Immunology/Inflammation; Microbiology/Virology
Purity:
0.9851
SMILES:
Cl.Cl.COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCCC1
Target:
CCR

References

1. Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17(1):64-73. 2. McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, Alpini G, DeMorrow S. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.