TargetMol

SEL120-34A

Product Code:
 
TAR-T10744
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10744-1mg1mg£148.00
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TAR-T10744-2mg2mg£214.00
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TAR-T10744-5mg5mg£295.00
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TAR-T10744-1mL1 mL * 10 mM (in DMSO)£321.00
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TAR-T10744-10mg10mg£406.00
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TAR-T10744-25mg25mg£629.00
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TAR-T10744-50mg50mg£864.00
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TAR-T10744-100mg100mg£1,139.00
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Further Information

Bioactivity:
SEL120-34A is a selective and ATP-competitive inhibitor of CDK8 with IC50s of 4.4 nM, 10.4 nM and 1070 nM for CDK8/CycC, CDK19/CycC and CDK9/cycT. SEL120-34A possesses antitumor activity.
CAS:
1609522-33-9
Formula:
C15H18Br2N4
Molecular Weight:
414.14
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9984
SMILES:
BrC1=C(Br)C2=C3C(N=C(N3CCC2)N4CCNCC4)=C1C
Target:
CDK

References

1. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.