TargetMol

Dihydroergocristine mesylate

Product Code:
 
TAR-T11043
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11043-1mg1mg£109.00
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TAR-T11043-5mg5mg£168.00
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TAR-T11043-1mL1 mL * 10 mM (in DMSO)£224.00
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TAR-T11043-10mg10mg£229.00
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TAR-T11043-25mg25mg£337.00
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TAR-T11043-50mg50mg£468.00
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TAR-T11043-100mg100mg£613.00
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Further Information

Bioactivity:
Dihydroergocristine mesylate(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of γ-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.
CAS:
24730-10-7
Formula:
C36H45N5O8S
Molecular Weight:
707.84
Pathway:
Neuroscience
Purity:
0.9965
SMILES:
CS(O)(=O)=O.CC(C)[C@@]1(NC(=O)[C@@H]2C[C@H]3[C@@H](Cc4c[nH]c5cccc3c45)N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
Target:
Beta Amyloid

References

1. Lei X, et al. The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-? peptides. Sci Rep. 2015 Nov 16;5:16541.