TargetMol

Elubrixin

Product Code:
 
TAR-T11179
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11179-1mg1mg£227.00
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TAR-T11179-5mg5mg£422.00
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TAR-T11179-1mL1 mL * 10 mM (in DMSO)£447.00
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TAR-T11179-10mg10mg£589.00
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TAR-T11179-25mg25mg£863.00
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TAR-T11179-50mg50mg£1,179.00
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TAR-T11179-100mg100mg£1,564.00
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TAR-T11179-500mg500mg£3,058.00
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Further Information

Bioactivity:
Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammation. Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist.
CAS:
688763-64-6
Formula:
C17H17Cl2FN4O4S
Molecular Weight:
463.31
Pathway:
GPCR/G Protein; Autophagy; Immunology/Inflammation
Purity:
1
SMILES:
Oc1c(NC(=O)Nc2cccc(F)c2Cl)ccc(Cl)c1S(=O)(=O)N1CCNCC1
Target:
IL Receptor; CXCR

References

1. Lazaar AL, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. 2. Nicholson GC, et al. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20(1):52-9. 3. Mozaffari S, et al. Inflammatory bowel disease therapies discontinued between 2009 and 2014. Expert Opin Investig Drugs. 2015;24(7):949-56.