TargetMol

ESI-08

Product Code:
 
TAR-T11234
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11234-1mg1mg£111.00
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TAR-T11234-5mg5mg£168.00
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TAR-T11234-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-T11234-10mg10mg£230.00
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TAR-T11234-25mg25mg£436.00
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TAR-T11234-50mg50mg£610.00
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Further Information

Bioactivity:
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
CAS:
301177-43-5
Formula:
C20H23N3OS
Molecular Weight:
353.48
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
Cc1ccc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
Target:
cAMP

References

1. Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.