TargetMol

F-1

Product Code:
 
TAR-T11254
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11254-1mg1mg£160.00
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TAR-T11254-5mg5mg£262.00
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TAR-T11254-1mL1 mL * 10 mM (in DMSO)£307.00
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TAR-T11254-10mg10mg£349.00
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TAR-T11254-25mg25mg£516.00
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TAR-T11254-50mg50mg£699.00
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Quantity:
TAR-T11254-100mg100mg£946.00
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Quantity:
TAR-T11254-500mg500mg£1,862.00
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This product comes from: United States.
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Further Information

Bioactivity:
?F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.?F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
CAS:
2244775-31-1
Formula:
C22H27ClN8O3S
Molecular Weight:
519.02
Pathway:
Immunology/Inflammation; Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9766
SMILES:
COc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
Target:
ROS; ALK; ROS Kinase

References

1. Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.