TargetMol

G150

Product Code:
 
TAR-T11344
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11344-1mg1mg£179.00
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TAR-T11344-5mg5mg£303.00
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TAR-T11344-1mL1 mL * 10 mM (in DMSO)£325.00
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TAR-T11344-10mg10mg£436.00
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TAR-T11344-25mg25mg£675.00
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TAR-T11344-50mg50mg£922.00
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Quantity:
TAR-T11344-100mg100mg£1,219.00
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Further Information

Bioactivity:
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
CAS:
2369751-30-2
Formula:
C18H16Cl2N4O2
Molecular Weight:
391.25
Pathway:
Immunology/Inflammation; DNA Damage/DNA Repair
Purity:
0.9739
SMILES:
Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO
Target:
DNA; cGAS

References

1. Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261.