TargetMol

Garcinol

Product Code:
 
TAR-T11366
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-T11366-25mg25mgEnquire
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TAR-T11366-50mg50mgEnquire
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TAR-T11366-1mg1mg£122.00
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TAR-T11366-5mg5mg£226.00
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TAR-T11366-1mL1 mL * 10 mM (in DMSO)£290.00
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TAR-T11366-10mg10mg£305.00
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Further Information

Bioactivity:
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
CAS:
78824-30-3
Formula:
C38H50O6
Molecular Weight:
602.812
Pathway:
Chromatin/Epigenetic; Apoptosis; Metabolism; Neuroscience
Purity:
0.98
SMILES:
CC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(=C(/O)c3ccc(O)c(O)c3)C1=O)C2=O)C(C)=C
Target:
Apoptosis; Endogenous Metabolite; Histone Acetyltransferase; AChR; AChE

References

1. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. 2. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86. 3. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.