TargetMol

GATA4-NKX2-5-IN-1

Product Code:
 
TAR-T11368
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11368-1mg1mg£145.00
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TAR-T11368-5mg5mg£254.00
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TAR-T11368-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-T11368-10mg10mg£369.00
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TAR-T11368-25mg25mg£576.00
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TAR-T11368-50mg50mg£790.00
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TAR-T11368-100mg100mg£1,050.00
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TAR-T11368-500mg500mg£2,038.00
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Further Information

Bioactivity:
GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.GATA4-NKX2-5-IN-1 ?dose-dependently inhibits the GATA4?NKX2-5 transcriptional synergy with an IC50 of 3 μM.
CAS:
544681-96-1
Formula:
C21H23N3O2
Molecular Weight:
349.434
Purity:
0.99
SMILES:
CCN(CC)c1ccc(NC(=O)c2c(C)onc2-c2ccccc2)cc1

References

1. V?lim?ki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60(18):7781-7798.