TargetMol

GCN2iB

Product Code:
 
TAR-T11375
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T11375-1mg1mg£132.00
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TAR-T11375-5mg5mg£213.00
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TAR-T11375-1mL1 mL * 10 mM (in DMSO)£228.00
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TAR-T11375-10mg10mg£302.00
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TAR-T11375-25mg25mg£533.00
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TAR-T11375-50mg50mg£733.00
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TAR-T11375-100mg100mg£978.00
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This product comes from: United States.
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Further Information

Bioactivity:
GCN2iB is an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM.
CAS:
2183470-12-2
Formula:
C18H12ClF2N5O3S
Molecular Weight:
451.83
Pathway:
Autophagy;
Purity:
0.9908
SMILES:
COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F
Target:
Autophagy

References

1. Nakamura A, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells by disrupting the amino acid response. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785.