TargetMol

Giredestrant

Product Code:
 
TAR-T11399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11399-1mg1mg£206.00
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TAR-T11399-2mg2mg£258.00
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TAR-T11399-5mg5mg£303.00
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TAR-T11399-1mL1 mL * 10 mM (in DMSO)£337.00
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TAR-T11399-10mg10mg£442.00
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TAR-T11399-25mg25mg£771.00
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TAR-T11399-50mg50mg£1,187.00
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TAR-T11399-100mg100mg£1,821.00
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TAR-T11399-200mg200mg£2,456.00
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Further Information

Bioactivity:
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
CAS:
1953133-47-5
Formula:
C27H31F5N4O
Molecular Weight:
522.564
Pathway:
Endocrinology/Hormones
Purity:
0.9896
SMILES:
C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)CO)c1c(F)cc(NC2CN(CCCF)C2)cc1F
Target:
Estrogen Receptor/ERR; Estrogen/progestogen Receptor

References

1. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes