TargetMol

Heptamidine dimethanesulfonate

Product Code:
 
TAR-T11553
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11553-1mg1mg£140.00
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TAR-T11553-5mg5mg£242.00
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TAR-T11553-1mL1 mL * 10 mM (in DMSO)£262.00
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TAR-T11553-10mg10mg£349.00
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TAR-T11553-25mg25mg£544.00
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TAR-T11553-50mg50mg£747.00
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TAR-T11553-100mg100mg£1,002.00
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TAR-T11553-500mg500mg£1,942.00
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Further Information

Bioactivity:
Heptamidine dimethanesulfonate is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM), selectively kills melanoma cells with S100B over those without S100B. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM).
CAS:
161374-55-6
Formula:
C23H36N4O8S2
Molecular Weight:
560.68
Purity:
0.9824
SMILES:
CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)c1ccc(OCCCCCCCOc2ccc(cc2)C(N)=N)cc1

References

1. McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett.?2012?Dec 13;3(12):975-979. Epub?2012?Sep 25. 2. Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol.?2013 Nov 15;8(11):2528-37.