TargetMol

JNJ-39758979

Product Code:
 
TAR-T11723L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11723L-1mg1mg£128.00
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Quantity:
TAR-T11723L-1mL1 mL * 10 mM (in DMSO)£220.00
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Quantity:
TAR-T11723L-5mg5mg£230.00
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Quantity:
TAR-T11723L-10mg10mg£328.00
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Quantity:
TAR-T11723L-25mg25mg£503.00
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Quantity:
TAR-T11723L-50mg50mg£696.00
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Quantity:
TAR-T11723L-100mg100mg£946.00
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Quantity:
TAR-T11723L-500mg500mg£1,821.00
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Quantity:
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Further Information

Bioactivity:
JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells.
CAS:
1046447-90-8
Formula:
C11H19N5
Molecular Weight:
221.308
Pathway:
GPCR/G Protein; Immunology/Inflammation; Neuroscience
Purity:
0.98
SMILES:
CC(C)c1cc(nc(N)n1)N1CC[C@@H](N)C1
Target:
Histamine Receptor

References

1. Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H? receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39. 2. Murata Y, et al. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.