TargetMol

KPLH1130

Product Code:
 
TAR-T11765
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11765-1mg1mg£132.00
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TAR-T11765-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T11765-5mg5mg£254.00
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TAR-T11765-10mg10mg£367.00
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TAR-T11765-25mg25mg£570.00
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TAR-T11765-50mg50mg£781.00
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Quantity:
TAR-T11765-100mg100mg£1,026.00
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TAR-T11765-500mg500mg£2,022.00
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Further Information

Bioactivity:
KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
CAS:
906669-07-6
Formula:
C15H13N3O3
Molecular Weight:
283.287
Pathway:
Metabolism; PI3K/Akt/mTOR signaling
Purity:
0.9843
SMILES:
Cc1ccc(cc1)-n1c(n[nH]c1=O)-c1ccc(O)cc1O
Target:
Dehydrogenase; PDK

References

1. Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.