TargetMol

MBM-55

Product Code:
 
TAR-T11960
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11960-1mg1mg£221.00
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TAR-T11960-5mg5mg£389.00
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TAR-T11960-1mL1 mL * 10 mM (in DMSO)£442.00
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TAR-T11960-10mg10mg£544.00
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TAR-T11960-25mg25mg£830.00
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TAR-T11960-50mg50mg£1,099.00
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Quantity:
TAR-T11960-100mg100mg£1,460.00
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Further Information

Bioactivity:
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
CAS:
2083622-09-5
Formula:
C28H27FN6O2
Molecular Weight:
498.562
Pathway:
Tyrosine Kinase/Adaptors; MAPK; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; PI3K/Akt/mTOR signaling; Angiogenesis; Chromatin/Epigenetic
Purity:
0.9998
SMILES:
CN(C)CCn1cc(cn1)-c1ccn2c(cnc2c1)-c1ccc(C(N)=O)c(OCc2cccc(F)c2)c1
Target:
GSK-3; MAPK; DYRK; Akt; Chk; Bcr-Abl; CDK; S6 Kinase; Aurora Kinase

References

1. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.