TargetMol

MCHR1 antagonist 2

Product Code:
 
TAR-T11966
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11966-1mg1mg£189.00
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TAR-T11966-5mg5mg£322.00
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TAR-T11966-1mL1 mL * 10 mM (in DMSO)£348.00
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TAR-T11966-10mg10mg£442.00
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TAR-T11966-25mg25mg£680.00
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TAR-T11966-50mg50mg£930.00
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TAR-T11966-100mg100mg£1,219.00
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TAR-T11966-500mg500mg£2,384.00
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Further Information

Bioactivity:
MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
CAS:
863115-70-2
Formula:
C23H21FN2O5
Molecular Weight:
424.428
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis; GPCR/G Protein
Purity:
0.98
SMILES:
Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1
Target:
HER; Melanin-concentrating Hormone Receptor (MCHR)

References

1. Lynch JK, et al. Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84.