TargetMol

PROTAC Mcl1 degrader-1

Product Code:
 
TAR-T11975
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11975-100mg100mgEnquire
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TAR-T11975-1mg1mg£437.00
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TAR-T11975-5mg5mg£724.00
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TAR-T11975-10mg10mg£1,066.00
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Further Information

Bioactivity:
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
CAS:
2163793-38-0
Formula:
C45H45BrN6O8S
Molecular Weight:
909.85
Pathway:
Apoptosis
Purity:
0.98
SMILES:
Brc1ccc(Sc2ccc3C(=O)N(CCNC(=O)CCCCC(=O)NCCCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)C(=O)c4cccc2c34)cc1
Target:
BCL

References

1. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.