TargetMol

Melagatran

Product Code:
 
TAR-T11994
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11994-1mg1mg£595.00
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TAR-T11994-5mg5mg£1,291.00
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TAR-T11994-1mL1 mL * 10 mM (in DMSO)£1,396.00
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TAR-T11994-10mg10mg£1,661.00
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TAR-T11994-25mg25mg£2,456.00
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TAR-T11994-50mg50mg£3,259.00
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TAR-T11994-100mg100mg£4,528.00
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This product comes from: United States.
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Further Information

Bioactivity:
Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion. Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin.
CAS:
159776-70-2
Formula:
C22H31N5O4
Molecular Weight:
429.521
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
NC(=N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)cc1
Target:
Thrombin

References

Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.