TargetMol

N-Desmethyl-Apalutamide

Product Code:
 
TAR-T12146
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12146-1mg1mg£230.00
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TAR-T12146-5mg5mg£436.00
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TAR-T12146-1mL1 mL * 10 mM (in DMSO)£464.00
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TAR-T12146-10mg10mg£598.00
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TAR-T12146-25mg25mg£863.00
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TAR-T12146-50mg50mg£1,163.00
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Quantity:
TAR-T12146-100mg100mg£1,540.00
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This product comes from: United States.
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Further Information

Bioactivity:
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
CAS:
1332391-11-3
Formula:
C20H13F4N5O2S
Molecular Weight:
463.41
Pathway:
Metabolism; Endocrinology/Hormones
Purity:
0.9783
SMILES:
NC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
Target:
P45; Androgen Receptor

References

1. P?rez-Ruixo C, et al. Population Pharmacokinetics of Apalutamide and its Active Metabolite N-Desmethyl-Apalutamide in Healthy and Castration-Resistant Prostate Cancer Subjects. Clin Pharmacokinet. 2019 Aug 20. 2. Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133 3. May MB, et al. Apalutamide: A new agent in the management of prostate cancer. J Oncol Pharm Pract. 2019 Dec;25(8):1968-1978.